Endocrine Abstracts

Introduction: Systemic mastocytosis is a form of mastocytosis in which mast cells accumulate in tissues and organs such as liver, spleen, bone and small intestines. Symptoms and signs differ based on which parts of the body are affected and vary from asymptomatic forms to highly aggresive forms with low survival rate. About 16% of patients with systemic mastocytosis have symptomatic fractures, but the presentation of systemic mastocytosis with vertebral fractures as first clin...

Gynecomastia is an uncommon clinical manifestation of hyperthyroidism, due to an imbalance between sexual hormones caused by thyroid hormones excess. Recognition of such unusual association is important to ensure appropriate treatment and to avoid unnecessary investigation. In hyperthyroidism, increased serum levels of SHBG binds testosterone with greater affinity than estradiol, resulting in relatively higher free estradiol compared with free testosterone levels and thereby c...

Abstract: Familial benign hypocalciuric hypercalcemia (FHH) is a rare AD disorder exhibiting benign hypercalcemia, inappropriately normal PTH levels and relative hypocalciuria, thus reflecting partial resistance to the normal effects of extracellular calcium on parathyroid glands and kidneys. We report a 74-year-old women, with no fracture history, with bisphosphonate osteoporosis treatment (2011-present), with HLA B 27 positive ankylosing spondylitis. The clinical exam reveal...